In the first half of the nineteenth century, large numbers of Swiss immigrants settled in the rural Midwest, particularly Ohio, Indiana, Illinois and Wisconsin. Cincinnati, Chicago and St. Louis were popular destinations. Immigrants who entered the United States through the port of New Orleans could take a riverboat up the Mississippi River to reach their final destination.
German-speaking immigrants continued to come to Ohio in large numbers after 1850, and set the cultural tone for many communities throughout the state. During the 1800s, they were the largest group of immigrants in Ohio. Cincinnati, in particular, was strongly influenced by its German population.